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INDUCTION OF CYTOCHROME-P450IA GENES (CYP1A) BY OMEPRAZOLE IN THE HUMAN ALIMENTARY-TRACT
被引:109
作者
:
MCDONNELL, WM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ANN ARBOR,MI 48104
MCDONNELL, WM
SCHEIMAN, JM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ANN ARBOR,MI 48104
SCHEIMAN, JM
TRABER, PG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ANN ARBOR,MI 48104
TRABER, PG
机构
:
[1]
UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ANN ARBOR,MI 48104
[2]
VET ADM MED CTR,ANN ARBOR,MI 48105
来源
:
GASTROENTEROLOGY
|
1992年
/ 103卷
/ 05期
关键词
:
D O I
:
10.1016/0016-5085(92)91171-Y
中图分类号
:
R57 [消化系及腹部疾病];
学科分类号
:
摘要
:
Cytochrome P450 enzymes are capable of converting procarcinogens into either active mutagens or inactive metabolites. Because the distribution of these enzymes may be important for tissue susceptibility to procarcinogens, the expression and induction of CYPlA genes in the human alimentary tract were investigated. Endoscopic biopsy specimens were obtained from buccal mucosa, esophagus, gastric body, antrum, duodenum, and colon of 6 healthy volunteers before and 1 week after taking 20 mg of omeprazole daily. Tissue specimens were analyzed for the presence of CYP1A1 and 1A2 transcripts using hybridization methods and the polymerase chain reaction. P450-dependent enzymatic activity was assessed by deethylation of ethoxyresorufin. CYP1Al messenger RNA (mRNA) and ethoxyresorufin activity were present constitutively in the duodenum of each volunteer. Omeprazole (20 mg/day for 1 week) induced CYP1A1 mRNA and enzymatic activity in 5 of 6 volunteers. The one individual who did not initially respond had a marked increase in both mRNA and enzymatic activity after receiving 60 mg of omeprazole daily for 1 week. After treatment with omeprazole, two individuals had low levels of CYP1A1 mRNA in several other alimentary tissues as well as low levels of CYP1A2 mRNA in the duodenum. The expression and induction by a pharmaceutical agent of CYP1A genes may have implications for intestinal metabolism of ingested xenobiotics including procarcinogens. © 1992.
引用
收藏
页码:1509 / 1516
页数:8
相关论文
共 44 条
[1]
Ames B. N., 1990, P NATL ACAD SCI USA, V87, P777
[2]
OMEPRAZOLE TREATMENT DOES NOT AFFECT THE METABOLISM OF CAFFEINE
ANDERSSON, T
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
ANDERSSON, T
BERGSTRAND, R
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
BERGSTRAND, R
CEDERBERG, C
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
CEDERBERG, C
ERIKSSON, S
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
ERIKSSON, S
LAGERSTROM, PO
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
LAGERSTROM, PO
SKANBERG, I
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
SKANBERG, I
[J].
GASTROENTEROLOGY,
1991,
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BURKE, MD
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
BURKE, MD
THOMPSON, S
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
THOMPSON, S
ELCOMBE, CR
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
ELCOMBE, CR
HALPERT, J
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
HALPERT, J
HAAPARANTA, T
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
HAAPARANTA, T
MAYER, RT
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
MAYER, RT
[J].
BIOCHEMICAL PHARMACOLOGY,
1985,
34
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3345
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CHELLY, J
论文数:
0
引用数:
0
h-index:
0
CHELLY, J
CONCORDET, JP
论文数:
0
引用数:
0
h-index:
0
CONCORDET, JP
KAPLAN, JC
论文数:
0
引用数:
0
h-index:
0
KAPLAN, JC
KAHN, A
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0
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0
h-index:
0
KAHN, A
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1989,
86
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CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[6]
CONNEY AH, 1982, CANCER RES, V42, P4875
[7]
STABLE EXPRESSION OF HUMAN CYTOCHROME-P450IA2 CDNA IN A HUMAN LYMPHOBLASTOID CELL-LINE - ROLE OF THE ENZYME IN THE METABOLIC-ACTIVATION OF AFLATOXIN-B1
CRESPI, CL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
CRESPI, CL
STEIMEL, DT
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
STEIMEL, DT
AOYAMA, T
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
AOYAMA, T
GELBOIN, HV
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
GELBOIN, HV
GONZALEZ, FJ
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
GONZALEZ, FJ
[J].
MOLECULAR CARCINOGENESIS,
1990,
3
(01)
: 5
-
8
[8]
QUANTITATIVE INTER-RELATIONSHIPS BETWEEN AFLATOXIN-B1 CARCINOGEN DOSE, INDOLE-3-CARBINOL ANTI-CARCINOGEN DOSE, TARGET ORGAN DNA ADDUCTION AND FINAL TUMOR RESPONSE
DASHWOOD, RH
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
DASHWOOD, RH
ARBOGAST, DN
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
ARBOGAST, DN
FONG, AT
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
FONG, AT
PEREIRA, C
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
PEREIRA, C
HENDRICKS, JD
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
HENDRICKS, JD
BAILEY, GS
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
BAILEY, GS
[J].
CARCINOGENESIS,
1989,
10
(01)
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181
[9]
DEWAZIERS I, 1990, J PHARMACOL EXP THER, V253, P387
[10]
OMEPRAZOLE IS AN ARYL HYDROCARBON-LIKE INDUCER OF HUMAN HEPATIC CYTOCHROME-P450
DIAZ, D
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
DIAZ, D
FABRE, I
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
FABRE, I
DAUJAT, M
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
DAUJAT, M
SAINTAUBERT, B
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
SAINTAUBERT, B
BORIES, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
BORIES, P
MICHEL, H
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
MICHEL, H
MAUREL, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
MAUREL, P
[J].
GASTROENTEROLOGY,
1990,
99
(03)
: 737
-
747
←
1
2
3
4
5
→
共 44 条
[1]
Ames B. N., 1990, P NATL ACAD SCI USA, V87, P777
[2]
OMEPRAZOLE TREATMENT DOES NOT AFFECT THE METABOLISM OF CAFFEINE
ANDERSSON, T
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
ANDERSSON, T
BERGSTRAND, R
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
BERGSTRAND, R
CEDERBERG, C
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
CEDERBERG, C
ERIKSSON, S
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
ERIKSSON, S
LAGERSTROM, PO
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
LAGERSTROM, PO
SKANBERG, I
论文数:
0
引用数:
0
h-index:
0
机构:
Research Laboratories, AB Hässle, Mölndal
SKANBERG, I
[J].
GASTROENTEROLOGY,
1991,
101
(04)
: 943
-
947
[3]
ETHOXYPHENOXAZONES, PENTOXYPHENOXAZONES, AND BENZYLOXYPHENOXAZONES AND HOMOLOGS - A SERIES OF SUBSTRATES TO DISTINGUISH BETWEEN DIFFERENT INDUCED CYTOCHROMES-P-450
BURKE, MD
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
BURKE, MD
THOMPSON, S
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
THOMPSON, S
ELCOMBE, CR
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
ELCOMBE, CR
HALPERT, J
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
HALPERT, J
HAAPARANTA, T
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
HAAPARANTA, T
MAYER, RT
论文数:
0
引用数:
0
h-index:
0
机构:
ICI PLC,CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND
MAYER, RT
[J].
BIOCHEMICAL PHARMACOLOGY,
1985,
34
(18)
: 3337
-
3345
[4]
ILLEGITIMATE TRANSCRIPTION - TRANSCRIPTION OF ANY GENE IN ANY CELL TYPE
CHELLY, J
论文数:
0
引用数:
0
h-index:
0
CHELLY, J
CONCORDET, JP
论文数:
0
引用数:
0
h-index:
0
CONCORDET, JP
KAPLAN, JC
论文数:
0
引用数:
0
h-index:
0
KAPLAN, JC
KAHN, A
论文数:
0
引用数:
0
h-index:
0
KAHN, A
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1989,
86
(08)
: 2617
-
2621
[5]
CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[6]
CONNEY AH, 1982, CANCER RES, V42, P4875
[7]
STABLE EXPRESSION OF HUMAN CYTOCHROME-P450IA2 CDNA IN A HUMAN LYMPHOBLASTOID CELL-LINE - ROLE OF THE ENZYME IN THE METABOLIC-ACTIVATION OF AFLATOXIN-B1
CRESPI, CL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
CRESPI, CL
STEIMEL, DT
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
STEIMEL, DT
AOYAMA, T
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
AOYAMA, T
GELBOIN, HV
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
GELBOIN, HV
GONZALEZ, FJ
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
GONZALEZ, FJ
[J].
MOLECULAR CARCINOGENESIS,
1990,
3
(01)
: 5
-
8
[8]
QUANTITATIVE INTER-RELATIONSHIPS BETWEEN AFLATOXIN-B1 CARCINOGEN DOSE, INDOLE-3-CARBINOL ANTI-CARCINOGEN DOSE, TARGET ORGAN DNA ADDUCTION AND FINAL TUMOR RESPONSE
DASHWOOD, RH
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
DASHWOOD, RH
ARBOGAST, DN
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
ARBOGAST, DN
FONG, AT
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
FONG, AT
PEREIRA, C
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
PEREIRA, C
HENDRICKS, JD
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
HENDRICKS, JD
BAILEY, GS
论文数:
0
引用数:
0
h-index:
0
机构:
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
OREGON STATE UNIV, DEPT STAT, CORVALLIS, OR 97331 USA
BAILEY, GS
[J].
CARCINOGENESIS,
1989,
10
(01)
: 175
-
181
[9]
DEWAZIERS I, 1990, J PHARMACOL EXP THER, V253, P387
[10]
OMEPRAZOLE IS AN ARYL HYDROCARBON-LIKE INDUCER OF HUMAN HEPATIC CYTOCHROME-P450
DIAZ, D
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
DIAZ, D
FABRE, I
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
FABRE, I
DAUJAT, M
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
DAUJAT, M
SAINTAUBERT, B
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
SAINTAUBERT, B
BORIES, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
BORIES, P
MICHEL, H
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
MICHEL, H
MAUREL, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, INSERM, U128, ROUTE MENDE, BP 5051, F-34033 MONTPELLIER, FRANCE
MAUREL, P
[J].
GASTROENTEROLOGY,
1990,
99
(03)
: 737
-
747
←
1
2
3
4
5
→