THE EXPRESSION OF FMS, KIT AND FLT3 IN HEMATOPOIETIC MALIGNANCIES

被引：35

作者：

BIRG, F

ROSNET, O

CARBUCCIA, N

BIRNBAUM, D

机构：

[1] Laboratoires d'Hématologie Moléculaire, Unité 119 de I'INSERM, 13009 Marseille

[2] D'Oncologie Moléculaire, Unité 119 de I'INSERM, 13009 Marseille

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 13卷 / 3-4期

关键词：

RECEPTOR TYROSINE KINASES; GENE EXPRESSION; ACUTE MYELOID LEUKEMIA; ACUTE LYMPHOID LEUKEMIA; HEMATOPOIESIS;

D O I：

10.3109/10428199409056285

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three receptor molecules, belonging to the class III of receptor tyrosine kinases, namely the receptors for colony-stimulating factor 1, CSF1R (product of the FMS proto-oncogene) and Steel factor, SLFR (product of the KIT proto-oncogene), as well as the recently identified FLT3/FLK2 gene product, appear to play distinct roles in normal hematopoietic differentiation. Their potential role in leukemic hematopoiesis has been approached by expression studies in hematopoietic malignancies, especially in acute leukemias of the myeloid and lymphoid lineages. We present here a review of available data, and discuss the possible significance and potential applications of these results.

引用

页码：223 / 227

页数：5

共 40 条

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