Enzymatic resolution of racemic ibuprofen esters: Effects of organic cosolvents and temperature

被引：50

作者：

Lee, WH ^{[1
]}

Kim, KJ ^{[1
]}

Kim, MG ^{[1
]}

Lee, SB ^{[1
]}

机构：

[1] POHANG UNIV SCI & TECHNOL,DEPT CHEM ENGN,POHANG 790784,SOUTH KOREA

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1995年 / 80卷 / 06期

关键词：

ibuprofen; enzymatic resolution; organic solvent; enantioselectivity; lipase; Candida cylindracea;

D O I：

10.1016/0922-338X(96)87742-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of organic additives on enzymatic hydrolysis of racemic ibuprofen methyl ester were investigated using Candida cylindracea lipase. Several polar solvents such as N,N-dimethylformamide, formaldehyde, and formamide were found to enhance the enantioselectivity of the enzyme. The effects of temperature on enzyme selectivity were also examined.

引用

页码：613 / 615

页数：3

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