EFFECTS OF DICLOFENAC SODIUM AND INDOMETHACIN ON PROLIFERATION AND COLLAGEN-SYNTHESIS OF LENS EPITHELIAL-CELLS IN-VITRO

被引：43

作者：

NISHI, O

NISHI, K

FUJIWARA, T

SHIRASAWA, E

机构：

[1] Nishi Eye Hospital, Osaka

[2] Central Research Center, Santen Pharmaceutical Co., Ltd., Osaka

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1995年 / 21卷 / 04期

关键词：

CYTOKINES; DICLOFENAC SODIUM; INDOMETHACIN; LENS EPITHELIAL CELL; POSTERIOR CAPSULE OPACIFICATION; POSTOPERATIVE INFLAMMATION;

D O I：

10.1016/S0886-3350(13)80541-X

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We investigated the effects of diclofenac sodium and indomethacin on the proliferation of and collagen synthesis by lens epithelial cells (LECs) of human cataracts in culture. The anterior capsule with attached LECs, obtained by anterior capsulotomy during cataract surgery, was cultured directly without cell dispersion. When the culture became almost confluent, diclofenac sodium or indomethacin at various concentrations was added to the incubation medium. The incorporation of H-3-thymidine and H-3-proline into the LECs was measured after the cells were labeled with these radioactive materials. Both drugs greatly suppressed the incorporation of H-3-thymidine and of 3H-proline, indicating that they inhibit cell division and collagen synthesis by LECs. Both drugs may help prevent posterior capsule opacification.

引用

页码：461 / 465

页数：5

共 22 条

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