NERVE GROWTH-FACTOR ACTS THROUGH CAMP-DEPENDENT PROTEIN-KINASE TO INCREASE THE NUMBER OF SODIUM-CHANNELS IN PC12 CELLS

被引：83

作者：

KALMAN, D ^{[1
]}

WONG, B ^{[1
]}

HORVAI, AE ^{[1
]}

CLINE, MJ ^{[1
]}

OLAGUE, PH ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT HEMATOL ONCOL,LOS ANGELES,CA 90024

来源：

NEURON | 1990年 / 4卷 / 03期

关键词：

D O I：

10.1016/0896-6273(90)90048-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

cAMP-dependent protein kinase (PKA) and phospholipid-dependent protein kinase (PKC) play a role in nerve growth factor (NGF)-mediated differentiation. In PC12 cells, NGF causes neurite outgrowth and increases the number of voltage-gated Na+ channels. Neurite outgrowth involves in part activation of PKC. How NGF regulates Na+ channel number is unknown. Using patch-clamp techniques, we find that agents activating PKC, including phorbol esters and a ras oncogene product (p21) that induces neurites caused little increase in channel number. In contrast, agents increasing intracellular cAMP were as effective as NGF A specific protein inhibitor of the PKA catalytic subunit blocked increases by NGF or cAMP Thus, NGF increases Na+ channel number in PC12 cells in part by activating PKA but apparently not PKC. © 1990.

引用

页码：355 / 366

页数：12

共 79 条

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