ASYMMETRIC DIHYDROXYLATION OF ACROLEIN ACETALS - SYNTHESIS OF STABLE EQUIVALENTS OF ENANTIOPURE GLYCERALDEHYDE AND GLYCIDALDEHYDE

被引：24

作者：

OI, R ^{[1
]}

SHARPLESS, KB ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 16期

关键词：

D O I：

10.1016/0040-4039(92)88149-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric dihydroxylation (ADH) of acrolein acetals afforded optically active glyceraldehyde equivalents. Enantiopure 3-(1,2-dihydroxyethyl)-1,5-dihydro-3H-2,4-benzodioxepine 3, a protected glyceraldehyde, was obtained from the corresponding acrolein acetal 2 by ADH and subsequent recrystallization. Enantiopure 3-(1,2-epoxyethyl)-1,5-dihydro-3H-2,4-benzodioxepine 5, a protected glycidaldehyde, was produced in two steps from 3.

引用

页码：2095 / 2098

页数：4

共 12 条

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