PHOTODYNAMIC THERAPY

被引:107
作者
LEVY, JG
机构
[1] at Quadra Logic Technologies Inc., Vancouver, BC V5Z 4H5
关键词
D O I
10.1016/S0167-7799(00)88895-2
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Photodynamic therapy (PDT) involves the use of a class of molecules that are activated by light, and which accumulate in, and are retained by, certain abnormal tissues. When these molecules (known as photosensitizers) are activated by light, they cause the formation of active forms of oxygen, which result in the killing of cells in which the photosensitizers are present. Thus, PDT can be used to destroy diseased areas of tissue selectively, while sparing the normal surrounding tissue. PDT has been extensively studied in the treatment of cancer, but the technology has potential as a treatment in a number of other disease conditions.
引用
收藏
页码:14 / 18
页数:5
相关论文
共 25 条
[1]  
DOIRON DR, 1994, 5TH P INT PHOT ASS, P45
[2]  
Dougherty T J, 1989, Oncology (Williston Park), V3, P67
[3]  
FINGAR VH, 1992, SPIE, V1645, P98
[4]   A PROSPECTIVE PHASE-II STUDY ON PHOTODYNAMIC THERAPY WITH PHOTOFRIN-II FOR CENTRALLY LOCATED EARLY-STAGE LUNG-CANCER [J].
FURUSE, K ;
FUKUOKA, M ;
KATO, H ;
HORAI, T ;
KUBOTA, K ;
KODAMA, N ;
KUSUNOKI, Y ;
TAKIFUJI, N ;
OKUNAKA, T ;
KONAKA, C ;
WADA, H ;
HAYATA, Y .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (10) :1852-1857
[5]  
GOMER CJ, 1989, SEMIN HEMATOL, V26, P27
[6]   OXYGEN LIMITATION OF DIRECT TUMOR-CELL KILL DURING PHOTODYNAMIC TREATMENT OF A MURINE TUMOR-MODEL [J].
HENDERSON, BW ;
FINGAR, VH .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1989, 49 (03) :299-304
[7]   PHOTODYNAMIC THERAPY FOR CANCERS - A CLINICAL-TRIAL OF PORFIMER SODIUM IN JAPAN [J].
KATO, H ;
HORAI, T ;
FURUSE, K ;
FUKUOKA, M ;
SUZUKI, S ;
HIKI, Y ;
ITO, Y ;
MIMURA, S ;
TENJIN, Y ;
HISAZUMI, H ;
HAYATA, Y .
JAPANESE JOURNAL OF CANCER RESEARCH, 1993, 84 (11) :1209-1214
[8]   HEMATOPORPHYRIN DERIVATIVE - POSSIBLE AID IN DIAGNOSIS AND THERAPY OF CARCINOMA OF BLADDER [J].
KELLY, JF ;
SNELL, ME .
JOURNAL OF UROLOGY, 1976, 115 (02) :150-151
[9]   PHOTODYNAMIC THERAPY WITH ENDOGENOUS PROTOPORPHYRIN .9. BASIC PRINCIPLES AND PRESENT CLINICAL-EXPERIENCE [J].
KENNEDY, JC ;
POTTIER, RH ;
PROSS, DC .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1990, 6 (1-2) :143-148
[10]  
LEVY JG, 1994, SPIE, V2078, P91