LOUISIANIN-A, LOUISIANIN-B, LOUISIANIN-C AND LOUISIANIN-D - NONSTEROIDAL GROWTH-INHIBITORS OF TESTOSTERONE-RESPONSIVE SC-115 CELLS .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

被引：16

作者：

KOMIYAMA, K ^{[1
]}

TAKAMATSU, S ^{[1
]}

KIM, YP ^{[1
]}

MATSUMOTO, A ^{[1
]}

TAKAHASHI, Y ^{[1
]}

HAYASHI, M ^{[1
]}

WOODRUFF, HB ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO INST,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 10期

关键词：

D O I：

10.7164/antibiotics.48.1086

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of screening for non-steroidal growth inhibitors of testosterone-responsive Shionogi carcinoma 115 cells, louisianins A, B, C and D, were isolated from fermentation broth of Streptomyces sp. WK-4028. Louisianin A remarkably inhibited the growth of SC 115 cells in the presence of 10(-7) M testosterone at an IC50 value of 0.6 mu g/ml, whereas, no inhibition was observed on the other cell lines. Furthermore, inhibitory activity of testosterone 5 alpha-reductase and antimicrobial activity have not been observed at a concentration of 50 mu g/ml and 1,000 mu g/ml, respectively.

引用

页码：1086 / 1089

页数：4

共 10 条

[1] CHEMICAL COMPOSITION OF CELL-WALL PREPARATIONS FROM STRAINS OF VARIOUS FORM-GENERA OF AEROBIC ACTINOMYCETES [J].