INVIVO O-17 NUCLEAR-MAGNETIC-RESONANCE FOR THE ESTIMATION OF CEREBRAL BLOOD-FLOW AND OXYGEN-CONSUMPTION

被引：39

作者：

ARAI, T

MORI, K

NAKAO, S

WATANABE, K

KITO, K

AOKI, M

MORI, H

MORIKAWA, S

INUBUSHI, T

机构：

[1] SHIGA UNIV MED SCI, MOLEC NEUROBIOL RES CTR, SHIGA, JAPAN

[2] YOKOGAWA MED SYST, TOKYO, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91911-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To explore the feasibility of in vivo 17O NMR for the estimation of cerebral blood flow and oxygen consumption, in vivo 17O NMR spectroscopy and imaging were employed in animal models. In the spectroscopy, the changes in the 17O NMR signal intensity after the injection of H217O and the inhalation of 17O2 gas were obtained every 4 seconds with sufficient signal-to-noise ratios for the quantification of cerebral blood flow and oxygen consumption. In the imaging, although the time and spatial resolutions were insufficient for the quantification of H217O, 17O NMR images of rabbit brain could be obtained, indicating that it is possible to map cerebral blood flow and oxygen consumption by 17O NMR imaging. © 1991.

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页码：954 / 961

页数：8

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