BIPOLAR-II DISORDER IN 6 SISTERS

被引:13
作者
DEPAULO, JR
SIMPSON, SG
GAYLE, JO
FOLSTEIN, SE
机构
[1] Johns Hopkins University School of Medicine, Baltimore, MD
关键词
Bipolar affective disorder; Bipolar II disorder; Familial occurence;
D O I
10.1016/0165-0327(90)90103-F
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Several studies have suggested the utility of separating the type II (BPII) from type I bipolar affective disorder (BPI). The data supporting this suggestion include differences in the course of BPII illness, poorer response of BPII to medications, the higher frequency in BPII patients of non-affective co-morbidity and an increased risk of BPII disorder among relatives of BPII patients. This report of a family in which six sisters and several other family members share the disorder further supports the suggestion that BPII disorder 'breeds true', at least in some families. Since the diagnosis of the BPII disorder is relatively unstable, further study will be needed to establish BPII as distinct from BPI and unipolar disorders. Among others, molecular genetic methods will be useful in the resolution of this issue. © 1990.
引用
收藏
页码:259 / 264
页数:6
相关论文
共 27 条
[21]   COURSE OF DEPRESSIVE PSYCHOSES [J].
PERRIS, C .
ACTA PSYCHIATRICA SCANDINAVICA, 1968, 44 (03) :238-&
[22]  
PERRIS C, 1966, ACTA PSYCHIAT SCAND, VS 42, P15
[23]   FAMILY HISTORY STUDIES .V. GENETICS OF MANIA [J].
REICH, T ;
CLAYTON, PJ ;
WINOKUR, G .
AMERICAN JOURNAL OF PSYCHIATRY, 1969, 125 (10) :1358-&
[24]   THE STABILITY OF DIAGNOSIS WITH AN APPLICATION TO BIPOLAR-II DISORDER [J].
RICE, JP ;
MCDONALDSCOTT, P ;
ENDICOTT, J ;
CORYELL, W ;
GROVE, WM ;
KELLER, MB ;
ALTIS, D .
PSYCHIATRY RESEARCH, 1986, 19 (04) :285-296
[25]   THE ESTIMATION OF DIAGNOSTIC SENSITIVITY USING STABILITY DATA - AN APPLICATION TO MAJOR DEPRESSIVE DISORDER [J].
RICE, JP ;
ENDICOTT, J ;
KNESEVICH, MA ;
ROCHBERG, N .
JOURNAL OF PSYCHIATRIC RESEARCH, 1987, 21 (04) :337-345
[26]   HLA AND GENETICS OF IDDM - HOLISM VS REDUCTIONISM [J].
SEGALL, M .
DIABETES, 1988, 37 (08) :1005-1008
[27]   RESEARCH DIAGNOSTIC CRITERIA - RATIONALE AND RELIABILITY [J].
SPITZER, RL ;
ENDICOTT, J ;
ROBINS, E .
ARCHIVES OF GENERAL PSYCHIATRY, 1978, 35 (06) :773-782