N-(CARBOBENZYLOXY)ISATIN - A SLOW BINDING ALPHA-KETO LACTAM INHIBITOR OF ALPHA-CHYMOTRYPSIN

被引：11

作者：

IYER, RA

HANNA, PE

机构：

[1] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00464-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The N-carbobenzyloxy derivative of 2,3-dioxindole (N-Cbz-isatin) (1) has been synthesized and shown to be a slow binding inhibitor of chymotrypsin. Compound 1 does not inhibit porcine pancreatic elastase. The N-tert-butoxycarbonyl derivative of 2,3-dioxindole (2) is a weak: inhibitor of chymotrypsin and does not inhibit porcine pancreatic elastase.

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页码：89 / 92

页数：4

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