SUBSTITUTED 3-OXO-1,25-THIADIAZOLIDINE 1,1-DIOXIDES - A NEW CLASS OF POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE AND CATHEPSIN-G

被引：27

作者：

GROUTAS, WC

KUANG, RZ

VENKATARAMAN, R

机构：

[1] Department of Chemistry, Wichita State University, Wichita

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 198卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion. © 1994 Academic Press, Inc.

引用

页码：341 / 349

页数：9

共 18 条

[1] AUF N, 1991, TETRAHEDRON LETT, V32, P6545
[2] BAGGIOLINI M, 1978, AGENTS ACTIONS, V8, P3, DOI 10.1007/BF01972395
[3] CRYSTAL RG, 1991, LUNG, V2
[4] INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY DERIVATIVES OF N-HYDROXYSUCCINIMIDE - A STRUCTURE ACTIVITY-RELATIONSHIP STUDY
GROUTAS, WC
BRUBAKER, MJ
STANGA, MA
CASTRISOS, JC
CROWLEY, JP
SCHATZ, EJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (07) : 1607 - 1611
[5] A GENERAL-APPROACH TOWARD THE DESIGN OF INHIBITORS OF SERINE PROTEINASES - INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY SUBSTITUTED DIHYDROURACILS
GROUTAS, WC
HUANG, H
EPP, JB
BRUBAKER, MJ
KELLER, CE
MCCLENAHAN, JJ
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (12) : 1565 - 1570
[6] HETEROCYCLIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE - 3-HYDROXYPYRIDAZOPYRIMIDINE, 3-HYDROXYPYRIDOPYRIMIDINE AND 3-HYDROXYQUINAZOLINE-2,4(1H,3H)DIONE DERIVATIVES
GROUTAS, WC
CASTRISOS, JC
STANGA, MA
KUANG, RZ
VENKATARAMAN, R
EPP, JB
BRUBAKER, MJ
CHONG, LS
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (06) : 1163 - 1168
[7] MECHANISM-BASED INHIBITORS OF SERINE PROTEINASES BASED ON THE GABRIEL-COLMAN REARRANGEMENT
GROUTAS, WC
CHONG, LS
VENKATARAMAN, R
EPP, JB
KUANG, RZ
BRUBAKER, MJ
HOUSERARCHIELD, N
HUANG, H
MCCLENAHAN, JJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (03) : 1491 - 1499
[8] INHIBITORS OF HUMAN NEUTROPHIL CATHEPSIN-G - STRUCTURAL AND BIOCHEMICAL-STUDIES
GROUTAS, WC
BRUBAKER, MJ
VENKATARAMAN, R
EPP, JB
STANGA, MA
MCCLENAHAN, JJ
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 294 (01) : 144 - 146
[9] 3-(ALKYLTHIO)-N-HYDROXYSUCCINIMIDE DERIVATIVES - POTENT INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
GROUTAS, WC
VENKATARAMAN, R
BRUBAKER, MJ
EPP, JB
CHONG, LS
STANGA, MA
MCCLENAHAN, JJ
TAGUSAGAWA, F
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1164 (03) : 283 - 288
[10] GROUTAS WC, 1993, IN PRESS BIOMED CHEM

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