SUBSTITUTED 3-OXO-1,25-THIADIAZOLIDINE 1,1-DIOXIDES - A NEW CLASS OF POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE AND CATHEPSIN-G

被引:27
作者
GROUTAS, WC
KUANG, RZ
VENKATARAMAN, R
机构
[1] Department of Chemistry, Wichita State University, Wichita
关键词
D O I
10.1006/bbrc.1994.1048
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion. © 1994 Academic Press, Inc.
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页码:341 / 349
页数:9
相关论文
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