TRANSCRIPTION REGULATES OXOLINIC ACID-INDUCED DNA GYRASE CLEAVAGE AT SPECIFIC SITES ON THE ESCHERICHIA-COLI CHROMOSOME

被引:33
作者
CONDEMINE, G
SMITH, CL
机构
[1] INST NATL SCI APPL,MICROBIOL LAB,BAT 406,20 AVE ALBERT EINSTEIN,F-69621 VILLEURBANNE,FRANCE
[2] UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,CTR HUMAN GENOME,BERKELEY,CA 94720
[3] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720
关键词
D O I
10.1093/nar/18.24.7389
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prominent DNA gyrase-mediated cleavage sites, induced by oxolinic acid, occur at specific, but infrequent, locations on the Escherichia coli chromosome. These sites, which we call toposites, may represent high affinity DNA gyrase binding sites or may mark chromosomal regions that accumulate superhelical stress. Toposites are usually grouped in 5 to 10 kb clusters that are mostly 50 to 100 kb apart. The total number of clusters on the chormosome is between 50 and 100. The location of sites depends on the local sequence. The extent of DNA gyrase cleavage at toposites can be strongly modulated by transcription occurring at as far as 35 kb away.
引用
收藏
页码:7389 / 7396
页数:8
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