ELECTRIC-STIMULATION REGULATES THE LEVEL OF CA-CHANNELS IN CHICK MUSCLE CULTURE

被引：10

作者：

FREUDSILVERBERG, M ^{[1
]}

SHAINBERG, A ^{[1
]}

机构：

[1] BAR ILAN UNIV,OTTO MEYERHOFF DRUG RECEPTOR CTR,DEPT LIFE SCI,IL-52900 RAMAT GAN,ISRAEL

来源：

NEUROSCIENCE LETTERS | 1993年 / 151卷 / 01期

关键词：

CA-CHANNEL; DHP RECEPTOR; ELECTRIC STIMULATION; MUSCLE CULTURE;

D O I：

10.1016/0304-3940(93)90057-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To examine the role of muscle activity in the expression of 1,4-dihydropyridine (DHP)-sensitive Ca-channels, we electrically stimulated chick skeletal muscle cells growing in culture. The number of Ca-channels was determined by a radioligand binding technique using [H-3]PN200-1 10. The function of these channels was measured by depolarization-induced Ca-45 uptake. We found that both the amount and the function of these channels were higher as a result of the increased muscle activity caused by electrical stimulation (ES).

引用

页码：104 / 106

页数：3

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