INFLUENCE OF ANETHOLE TREATMENT ON THE TUMOR-INDUCED BY EHRLICH ASCITES-CARCINOMA CELLS IN PAW OF SWISS ALBINO MICE

被引:51
作者
ALHARBI, MM
QURESHI, S
RAZA, M
AHMED, MM
GIANGRECO, AB
SHAH, AH
机构
[1] KING SAUD UNIV,COLL PHARM,CTR EXPTL ANIM CARE,QUAL CONTROL & RES LAB,RIYADH 11451,SAUDI ARABIA
[2] MOH,CENT LAB DRUG & FOOD ANAL,RIYADH 11525,SAUDI ARABIA
关键词
ANETHOLE; ANTICARCINOGENICITY; EHRLICH ASCITES; TUMOR;
D O I
10.1097/00008469-199508000-00006
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The anticarcinogenic potential of anethole was studied in Ehrlich ascites tumour (EAT) in the paw of Swiss albino mice, The antitumour activity was evaluated from the cytotoxicity of EAT-cells in the paw and their biochemical changes were determined from nucleic acids, protein, malondialdehyde (MDA) and glutathione (NP-SH) concentrations, Furthermore, the observations on survival rate, tumour weight, its volume and body weight of EAT-bearing mice were made, The EAT-bearing paws were also evaluated for histopathological changes, Additional studies were undertaken on the cytological effects of anethole in order to establish its clastogenic and mitodepressive activity in normal mice, The results obtained in the present study revealed anethole to increase the survival time, reduce the tumour weight and volume and body weight of the EAT-bearing mice, It caused a significant cytotoxic effect in EAT cells in the paw, reduced the levels of nucleic acids and MDA, and increased NP-SH concentrations, The histopathological changes observed after treatment with anethole were comparable to the standard cytotoxic drug cyclophosphamide, The results on the frequency of micronuclei and the ratio of polychromatic erythrocytes to normochromatic erythrocytes showed anethole to be mitodepressive and non-clastogenic in the femoral cells of mice, Our results indicate the anticarcinogenic, cytotoxic and non-clastogenic nature of anethole, Further studies are warranted to explore the mode of action and safety of anethole for its possible use in cancer therapy.
引用
收藏
页码:307 / 318
页数:12
相关论文
共 40 条
[31]  
SADLAK J, 1968, ANAL BIOCHEM, V25, P192
[32]   GENOTOXICITY OF SAFROLE-RELATED CHEMICALS IN MICROBIAL TEST SYSTEMS [J].
SEKIZAWA, J ;
SHIBAMOTO, T .
MUTATION RESEARCH, 1982, 101 (02) :127-140
[33]  
SMITH MT, 1984, DRUG METABOLISM DRUG, P71
[34]  
STAHL E, 1982, DTSCH APOTHEKER ZEIT, V122, P2324
[35]   EFFECTS OF OLTIPRAZ, BHA, ADT AND CABBAGE ON GLUTATHIONE METABOLISM, DNA DAMAGE AND LIPID-PEROXIDATION IN OLD MICE [J].
STOHS, SJ ;
LAWSON, TA ;
ANDERSON, L ;
BUEDING, E .
MECHANISMS OF AGEING AND DEVELOPMENT, 1986, 37 (02) :137-145
[36]   MUTAGENICITIES OF SAFROLE, ESTRAGOLE, EUGENOL, TRANS-ANETHOLE, AND SOME OF THEIR KNOWN OR POSSIBLE METABOLITES FOR SALMONELLA-TYPHIMURIUM MUTANTS [J].
SWANSON, AB ;
CHAMBLISS, DD ;
BLOMQUIST, JC ;
MILLER, EC ;
MILLER, JA .
MUTATION RESEARCH, 1979, 60 (02) :143-153
[37]   CHRONIC TOXICITY CARCINOGENICITY STUDY OF TRANS-ANETHOLE IN RATS [J].
TRUHAUT, R ;
LEBOURHIS, B ;
ATTIA, M ;
GLOMOT, R ;
NEWMAN, J ;
CALDWELL, J .
FOOD AND CHEMICAL TOXICOLOGY, 1989, 27 (01) :11-20
[38]   PROTECTIVE EFFECT OF ANETHOL DITHIOLTHIONE AGAINST ACETAMINOPHEN HEPATOTOXICITY IN MICE [J].
WARNET, JM ;
CHRISTEN, MO ;
THEVENIN, M ;
BIARD, D ;
JACQUESON, A ;
CLAUDE, JR .
PHARMACOLOGY & TOXICOLOGY, 1989, 65 (01) :63-64
[39]  
WISEMAN RW, 1987, CANCER RES, V47, P2275
[40]   SINGLE-CELL PLATINGS FROM FRESHLY ISOLATED MAMMALIAN TISSUE [J].
ZAROFF, L ;
SATO, G ;
MILLS, SE .
EXPERIMENTAL CELL RESEARCH, 1961, 23 (03) :565-&