ENHANCED EXPRESSION OF COMMON FRAGILE SITE WITH OCCUPATIONAL EXPOSURE TO PESTICIDES

被引：33

作者：

SBRANA, I

MUSIO, A

机构：

[1] Dipartimento di Scienze dell'Ambiente e del Territorio, Università di Pisa, Pisa

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 82卷 / 02期

关键词：

D O I：

10.1016/0165-4608(95)00020-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of common fragile sites (FS), induced by aphidicolin, in subjects with occupational history of exposure to pesticides has been studied. Results showed a higher frequency of FS in exposed subjects; in particular, there was an elevated expression of FS at the cancer breakpoints 3p14, 5q31, 7q22, 7q32, 14q24, and 16q22, involved in leukemias and non-Hodgkin's lymphoma. Moreover, the frequency of breaks in chromosomal bands carrying oncogenes or tumor suppressor genes involved in aberrations was significantly higher in exposed subjects at sites 1q25, 3p25, 7p22, 8q24.1, and 13q14.

引用

页码：123 / 127

页数：5

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