INFLUENCE OF AGE AND STRUCTURE OF PENICILLIUM-CHRYSOGENUM PELLETS ON THE INTERNAL CONCENTRATION PROFILES

被引：31

作者：

CRONENBERG, CCH ^{[1
]}

OTTENGRAF, SPP ^{[1
]}

VANDENHEUVEL, JC ^{[1
]}

POTTEL, F ^{[1
]}

SZIELE, D ^{[1
]}

SCHUGERL, K ^{[1
]}

BELLGARDT, KH ^{[1
]}

机构：

[1] UNIV HANNOVER,INST TECH CHEM,D-30167 HANNOVER,GERMANY

来源：

BIOPROCESS ENGINEERING | 1994年 / 10卷 / 5-6期

关键词：

D O I：

10.1007/BF00369531

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pellets of Penicillium chrysogenum which were spontaneously formed after a certain stage of a batch fermentation, displayed a considerable structural change in course of their lifetime. Microelectrode studies showed the internal mass transport properties of these pellets (diameter 1-3 mm) to be highly effected by their morphological structure. Relatively young pellets, in an early stage of the batch fermentation, possessed a homogeneous and dense structure. These pellets were only partly penetrated by oxygen (ca. 70 mum) at air saturated bulk conditions. Older pellets, in a final stage of the batch fermentation, were stratified and fluffy. They were completely penetrated by oxygen due to a decreased activity and a higher diffusivity. Investigations with glucose microelectrodes revealed that glucose consumption inside pellets of all lifetimes exclusively occurred in the periphery, indicating that growth was restricted to these regions only.

引用

页码：209 / 216

页数：8

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