A RATIONAL BASIS FOR THE MEASUREMENT OF FREE PHENYTOIN CONCENTRATION IN CRITICALLY ILL TRAUMA PATIENTS

被引：39

作者：

ZIELMANN, S

MIELCK, F

KAHL, R

KAZMAIER, S

SYDOW, M

KOLK, J

BURCHARDI, H

机构：

[1] UNIV HOSP GRONINGEN,DEPT ANAESTHESIOL,INTENS CARE & EMERGENCY,GRONINGEN,GERMANY

[2] UNIV HOSP GRONINGEN,DEPT CLIN PHARMACOL,GRONINGEN,GERMANY

来源：

THERAPEUTIC DRUG MONITORING | 1994年 / 16卷 / 02期

关键词：

PHENYTOIN-FREE FRACTION; CRITICALLY ILL PATIENTS;

D O I：

10.1097/00007691-199404000-00005

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was less-than-or-equal-to 10%, whereas in 76%, the free phenytoin fraction was increased >10%-up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.

引用

页码：139 / 144

页数：6

共 29 条

[1] EVALUATION OF AN ULTRAFILTRATION FLUORESCENCE POLARIZATION IMMUNOASSAY FOR MONITORING UNBOUND PHENYTOIN [J].