CHARACTERIZATION OF ANTI-HIV LIGNANS FROM LARREA-TRIDENTATA

被引：44

作者：

GNABRE, J

HUANG, RCC

BATES, RB

BURNS, JJ

CALDERA, S

MALCOMSON, ME

MCCLURE, KJ

机构：

[1] JOHNS HOPKINS UNIV,DEPT BIOL,BALTIMORE,MD 21218

[2] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

来源：

TETRAHEDRON | 1995年 / 51卷 / 45期

关键词：

D O I：

10.1016/0040-4020(95)00794-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fractions from Larrea tridentata with anti-HIV-1 activity (specifically, inhibition of HIV Tat transactivation) were analyzed by GC/MS and NMR and found to contain lignans 1a-i and 2a-d. Assay-guided purification by countercurrent chromatography established Ig (mal.4) to be especially active. Compounds Ib-f,h,i and 2d are new.

引用

页码：12203 / 12210

页数：8