ALTERATIONS IN THE CARBOHYDRATE STRUCTURES OF AN ABNORMAL PROTEIN FROM SERA OF PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：3

作者：

ENDO, T

ODA, O

YAMANAKA, N

MAEDA, K

YOSHIDA, M

KOBATA, A

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT BIOCHEM,MINATO KU,TOKYO 108,JAPAN

[2] BIODYNAM RES INST,TENPAKU KU,NAGOYA 468,JAPAN

[3] NAGOYA UNIV BRANCH HOSP,HIGASHI KU,NAGOYA 461,JAPAN

[4] ASAHI MED CO,OITA 87003,JAPAN

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1993年 / 307卷 / 01期

关键词：

D O I：

10.1006/abbi.1993.1569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G4-11, an abnormal immunoglobulin G4 (IgG4) glycoprotein, highly purified from the sera of patients with rheumatoid arthritis and from healthy individuals, contains two asparagine-linked sugar chains in one molecule. Comparative studies of the sugar chains released by bydrazinolysis revealed that the structures of the sugar chains of rheumatoid arthritis G4-11 are quite different from those of normal individuals. Although all G4-11 contained biantennary complex-type oligosaccharides like in the case of serum IgGs, samples from patients with rheumatoid arthritis had less galactosylated forms than those from normal individuals. These results indicated that this galactose deficiency of the sugar chains occurs in the abnormal IgG4 molecule of rheumatoid arthritis patients, just as was found in whole serum IgG. © 1993 Academic Press. All rights reserved.

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页码：119 / 125

页数：7

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