INDUCTION OF INFLAMMATORY ARTHROPATHY RESEMBLING RHEUMATOID-ARTHRITIS IN MICE TRANSGENIC FOR HTLV-I

被引：301

作者：

IWAKURA, Y

TOSU, M

YOSHIDA, E

TAKIGUCHI, M

SATO, K

KITAJIMA, I

NISHIOKA, K

YAMAMOTO, K

TAKEDA, T

HATANAKA, M

YAMAMOTO, H

SEKIGUCHI, T

机构：

[1] TOKYO WOMENS MED COLL, INST RHEUMATOL, SHINJUKU KU, TOKYO 163, JAPAN

[2] UNIV TOKYO, FAC MED, BUNKYO KU, TOKYO 113, JAPAN

[3] KYOTO UNIV, CHEST DIS RES INST, SAKYO KU, KYOTO 606, JAPAN

[4] KYOTO UNIV, INST VIRUS RES, SAKYO KU, KYOTO 606, JAPAN

[5] KOHNO CLIN MED RES INST, SHINAGAWA KU, TOKYO 140, JAPAN

来源：

SCIENCE | 1991年 / 253卷 / 5023期

关键词：

D O I：

10.1126/science.1887217

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human T cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T cell leukemia and has also been suggested to be involved in other diseases such as chronic arthritis or myelopathy. To elucidate pathological roles of the virus in disease, transgenic mice were produced that carry the HTLV-I genome. At 2 to 3 months of age, many of the mice developed chronic arthritis resembling rheumatoid arthritis. Synovial and periarticular inflammation with articular erosion caused by invasion of granulation tissues were marked. These observations suggest a possibility that HTLV-I is one of the etiologic agents of chronic arthritis in humans.

引用

页码：1026 / 1028

页数：3

共 32 条

[1] CYTOKINES AND CYTOKINE INHIBITORS OR ANTAGONISTS IN RHEUMATOID-ARTHRITIS [J].