DIFFERENTIAL SCANNING CALORIMETRY AS A QUICK SCANNING TECHNIQUE FOR SOLID-STATE STABILITY STUDIES

被引：35

作者：

VENKATARAM, S ^{[1
]}

KHOHLOKWANE, M ^{[1
]}

WALLIS, SH ^{[1
]}

机构：

[1] BIOVAIL CORP INT,STEINBACH,MB R0A 2T3,CANADA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 07期

关键词：

SOLID STATE INTERACTIONS; DSC; PREFORMULATION; EXCIPIENT COMPATABILITY;

D O I：

10.3109/03639049509026649

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The potential compatabilities of various commonly used excipients with Indomethacin (IMC) were compared using differential scanning calorimetry (DSC). Some agents were found to have no solid state interaction whereas others showed major changes in the thermograms signifying possible interactions in the solid state. The results show that DSC can be employed in preliminary preformulation studies for the evaluation of solid state interactions as an aid to excipient selection.

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页码：847 / 855

页数：9

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