MURIHEXOCIN-A AND MURIHEXOCIN-B, 2 NOVEL MONO-THF ACETOGENINS WITH 6 HYDROXYLS, FROM ANNONA-MURICATA (ANNONACEAE)

被引：29

作者：

ZENG, L ^{[1
]}

WU, FE ^{[1
]}

GU, ZM ^{[1
]}

MCLAUGHLIN, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACEUT SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 30期

关键词：

D O I：

10.1016/0040-4039(95)01017-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel bioactive acetogenins, murihexocins A (1) and B (2), were isolated from the leaves of the sour sop tree, Annona muricata (Annonaceae). 1 and 2 are C-35 mono-tetrahydrofuran (THF) acetogenins having six hydroxyls, and their structures have been elucidated by spectroscopic analyses and derivations. No Annonaceous acetogenins having six hydroxyls or with two vicinal diol groups have been reported previously. 1 and 2 showed significant inhibitory effects among six human tumor cell lines with interesting selectivities to the prostate (PC-3) and pancreatic (PACA-2) cell lines.

引用

页码：5291 / 5294

页数：4

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