Updating the CTD Story: From Tail to Epic

被引：30

作者：

Bartkowiak, Bartlomiej ^{[1
]}

MacKellar, April L. ^{[1
]}

Greenleaf, Arno L. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Ctr RNA Biol, Dept Biochem, Durham, NC 27710 USA

来源：

GENETICS RESEARCH INTERNATIONAL | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/623718

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Eukaryotic RNA polymerase II (RNAPII) not only synthesizes mRNA but also coordinates transcription-related processes via its unique C-terminal repeat domain (CTD). The CTD is an RNAPII-specific protein segment consisting of repeating heptads with the consensus sequence Y1S2P3T4S5P6S7 that has been shown to be extensively post-transcriptionally modified in a coordinated, but complicated, manner. Recent discoveries of new modifications, kinases, and binding proteins have challenged previously established paradigms. In this paper, we examine results and implications of recent studies related to modifications of the CTD and the respective enzymes; we also survey characterizations of new CTD-binding proteins and their associated processes and new information regarding known CTD-binding proteins. Finally, we bring into focus new results that identify two additional CTD-associated processes: nucleocytoplasmic transport of mRNA and DNA damage and repair.

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