THE GENE FOR HUMAN NEURON SPECIFIC UBIQUITIN C-TERMINAL HYDROLASE (UCHL1, PGP9.5) MAPS TO CHROMOSOME 4P14

被引：14

作者：

EDWARDS, YH ^{[1
]}

FOX, MF ^{[1
]}

POVEY, S ^{[1
]}

HINKS, LJ ^{[1
]}

THOMPSON, RJ ^{[1
]}

DAY, INM ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,SOUTHAMPTON S09 4XY,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1991年 / 55卷

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1469-1809.1991.tb00853.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ubiquitin carboxyl terminal hydrolase 1, UCHL1, is a neurone-specific protein involved in the ubiquitin-mediated proteolytic pathway. The gene for human UCHL1 has been mapped to chromosome 4 using the polymerase chain reaction to amplify specifically the human UCHL1 sequences in rodent/human somatic cell hybrid DNA. A regional assignment of this locus to 4p14 has been made by in situ hybridization to metaphase chromosomes using both tritium and fluorescently labelled probes.

引用

页码：273 / 278

页数：6

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