LOW-DOSE TETRAHYDROAMINOACRIDINE (THA) IMPROVES COGNITIVE FUNCTION BUT DOES NOT AFFECT BRAIN ACETYLCHOLINE IN RATS

被引：39

作者：

HODGES, H ^{[1
]}

RIBEIRO, AM ^{[1
]}

GRAY, JA ^{[1
]}

MARCHBANKS, RM ^{[1
]}

机构：

[1] INST PSYCHIAT,DEPT BIOCHEM,LONDON SE5 8AF,ENGLAND

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 02期

基金：

英国惠康基金;

关键词：

Acetylcholine; Acetylcholinesterase inhibition; Chronic alcohol; Nucleus basalis; medial septal and diagonal band lesions; Radial maze; Rat; Reference memory; Tetrahydroaminoacridine (THA); Working memory;

D O I：

10.1016/0091-3057(90)90406-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Eight days of treatment with two low doses of tetrahydroaminoacridine (THA), given once daily, substantially improved radial maze performance in two groups of rats which showed persistent deficits either after ibotenic acid lesions at the source at the source of forebrain cholinergic projections, or after 28 weeks treatment with alcohol (20% v/v) in drinking water. However, in immature, aged or aged and alcohol-treated rats, acetylcholine content was not significantly affected in any of the brain areas measured, even though the treatment regime had proved behaviourally effective. Inhibition of brain acetylcholinesterase activity was only marginally increased by this treatment regime. Thus, if THA influences behaviour by enhancing cholonergic transmission, its effects do not appear to be related to its activity as a cholinesterase inhibitor, and alternative mechanisms of action should be investigated. © 1990.

引用

页码：291 / 298

页数：8

共 34 条

[1] CHOLINERGIC-RICH BRAIN TRANSPLANTS REVERSE ALCOHOL-INDUCED MEMORY DEFICITS
ARENDT, T
ALLEN, Y
SINDEN, J
SCHUGENS, MM
MARCHBANKS, RM
LANTOS, PL
GRAY, JA
[J]. NATURE, 1988, 332 (6163) : 448 - 450
[2] EFFECTS OF PROLONGED ETHANOL-CONSUMPTION ON CHOLINERGIC FUNCTION IN THE BASAL FOREBRAIN AND MEMORY
ARENDT, T
MARCHBANKS, R
GRAY, JA
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1987, 15 (03) : 499 - 500
[3] LOSS OF NEURONS IN THE NUCLEUS BASALIS OF MEYNERT IN ALZHEIMERS-DISEASE, PARALYSIS AGITANS AND KORSAKOFFS DISEASE
ARENDT, T
BIGL, V
ARENDT, A
TENNSTEDT, A
[J]. ACTA NEUROPATHOLOGICA, 1983, 61 (02) : 101 - 108
[4] ARENDT T, IN PRESS NEUROSCIENC
[5] THE CHOLINERGIC HYPOTHESIS - A HISTORICAL OVERVIEW, CURRENT PERSPECTIVE, AND FUTURE-DIRECTIONS
BARTUS, RT
DEAN, RL
PONTECORVO, MJ
FLICKER, C
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 444 (MAY) : 332 - 358
[6] TETRAHYDROAMINOACRIDINE, 3,4 DIAMINOPYRIDINE AND PHYSOSTIGMINE - DIRECT COMPARISON OF EFFECTS ON MEMORY IN AGED PRIMATES
BARTUS, RT
DEAN, RL
[J]. NEUROBIOLOGY OF AGING, 1988, 9 (04) : 351 - 356
[7] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION
BARTUS, RT
DEAN, RL
BEER, B
LIPPA, AS
[J]. SCIENCE, 1982, 217 (4558) : 408 - 417
[8] BECKER RE, 1988, CURRENT RES ALZHEIME, P1
[9] DRACHMAN DA, 1974, ARCH NEUROL-CHICAGO, V30, P110
[10] 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE (THA), AN ALLEGED DRUG FOR THE TREATMENT OF ALZHEIMERS-DISEASE, INHIBITS ACETYLCHOLINESTERASE ACTIVITY AND SLOW OUTWARD K+ CURRENT
DRUKARCH, B
KITS, KS
VANDERMEER, EG
LODDER, JC
STOOF, JC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 141 (01) : 153 - 157

← 1 2 3 4 →