CENTRALLY INJECTED NEUROPEPTIDE-Y (13-36) PRODUCES VASOPRESSOR EFFECTS AND ANTAGONIZES THE VASODEPRESSOR ACTION OF NEUROPEPTIDE-Y (1-36) IN THE AWAKE MALE-RAT

被引：35

作者：

AGUIRRE, JA

FUXE, K

AGNATI, LF

VONEULER, G

机构：

[1] KAROLINSKA INST, DEPT HISTOL & NEUROBIOL, BOX 60400, S-10401 STOCKHOLM 60, SWEDEN

[2] UNIV MODENA, DEPT HUMAN PHYSIOL, I-41100 MODENA, ITALY

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

关键词：

Blood pressure; Brain; Intraventricular injection; Neuropeptide Y fragment; Neuropeptide Y receptors; Rat;

D O I：

10.1016/0304-3940(90)90235-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraventricular injections of the Y2 neuropeptide Y (NPY) receptor agonist porcine NPY (13-36) (pNPY (13-36); 25-3000 pmol) produced a dose-dependent increase (up to 14%; ED50 value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake, unrestrained male rat without affecting heart rate. Furthermore, a subthreshold dose of pNPY (13-36) (25 pmol) counteracted the vasodepressor action of the parent compound pNPY (1-36) (75 pmol), which also acts at NPY receptors of the Y1 type. These results suggest that NPY receptors of the Y1 and Y2 type have opposing actions in central cardiovascular regulation. © 1990.

引用

页码：5 / 8

页数：4

共 21 条

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FUXE K, 1990, PROGR BRAIN RES, P341

[12] STUDIES ON NEUROPEPTIDE-Y CATECHOLAMINE INTERACTIONS IN CENTRAL CARDIOVASCULAR REGULATION IN THE ALPHA-CHLORALOSE ANESTHETIZED RAT - EVIDENCE FOR A POSSIBLE NEW WAY OF ACTIVATING THE ALPHA-2 ADRENERGIC TRANSMISSION-LINE [J].