TNF-ALPHA INCREASES THE FREQUENCY OF SPONTANEOUS MINIATURE SYNAPTIC CURRENTS IN CULTURED RAT HIPPOCAMPAL-NEURONS

被引：50

作者：

GRASSI, F

MILEO, AM

MONACO, L

PUNTURIERI, A

SANTONI, A

EUSEBI, F

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00161 ROME,ITALY

[2] UNIV ROMA LA SAPIENZA,IST ISTOL,I-00161 ROME,ITALY

来源：

BRAIN RESEARCH | 1994年 / 659卷 / 1-2期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; TNF RECEPTOR; CULTURED HIPPOCAMPAL NEURON; MINIATURE SYNAPTIC CURRENT; SPONTANEOUS SYNAPTIC ACTIVITY;

D O I：

10.1016/0006-8993(94)90883-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha) is a cytokine secreted by activated astrocytes and is known to alter evoked synaptic activity in slices of adult rat hippocampus. In this paper we show that TNF-alpha increases the frequency of spontaneous miniature synaptic currents in cultured hippocampal neurons, acting at nanomolar concentrations. In addition, we show that the mRNA for the 55 kDa TNF-alpha receptor (TNF-R1) is detected in embryonic rat hippocampal cultures, as well as in acutely dissected embryonic and adult rat hippocampi. Possible transduction pathways mediating the TNF-alpha effect are discussed.

引用

页码：226 / 230

页数：5

共 28 条

[1] TUMOR NECROSIS FACTOR-ALPHA ENHANCES INTERFERON-GAMMA-MEDIATED CLASS-II ANTIGEN EXPRESSION ON ASTROCYTES [J].