HYDROPHOBICITY MEASUREMENTS BY HPLC - A NEW APPROACH TO PI-CONSTANTS

被引：11

作者：

GAGO, F

ALVAREZBUILLA, J

ELGUERO, J

机构：

[1] UNIV ALCALA HENARES,DEPT QUIM ORGAN,ALCALA HENARES,SPAIN

[2] CSIC,INST QUIM MED,E-28006 MADRID,SPAIN

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1987年 / 10卷 / 06期

关键词：

ORGANIC COMPOUNDS - Chromatographic Analysis;

D O I：

10.1080/01483918708066752

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A classical HPLC method of measuring log P//o///D w has been reevaluated and applied to 107 different mono- and disubstituted benzenes. The contribution of several functional groups has been estimated through multiple regression analysis, obtaining statistically significant mean pi //m values. Deviations of experimentally determined log P* values for a set of ortho-, meta-, and para- disubstituted isomers from the 'simple additive' model have been evaluated, and interpretations are suggested.

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页码：1031 / 1047

页数：17

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