INTERLEUKIN-11 INHIBITS BONE-FORMATION IN-VITRO

被引：56

作者：

HUGHES, FJ

HOWELLS, GL

机构：

[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL MED & PERIODONTOL,TURNER ST,LONDON E1 2AD,ENGLAND

[2] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL PATHOL,LONDON E1 2AD,ENGLAND

来源：

CALCIFIED TISSUE INTERNATIONAL | 1993年 / 53卷 / 05期

关键词：

D O I：

10.1007/BF01351844

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.

引用

页码：362 / 364

页数：3

共 16 条

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[2] MINERALIZED BONE NODULES FORMED INVITRO FROM ENZYMATICALLY RELEASED RAT CALVARIA CELL-POPULATIONS [J].