A THEORY FOR THE PRIMARY AND SECONDARY DRYING STAGES OF THE FREEZE-DRYING OF PHARMACEUTICAL CRYSTALLINE AND AMORPHOUS SOLUTES - COMPARISON BETWEEN EXPERIMENTAL-DATA AND THEORY

被引：77

作者：

LIAPIS, AI

BRUTTINI, R

机构：

[1] Department of Chemical Engineering, Biochemical Processing Institute, University of Missouri-Rolla, Rolla, MO

来源：

SEPARATIONS TECHNOLOGY | 1994年 / 4卷 / 03期

关键词：

FREEZE-DRYING OF PHARMACEUTICALS; LYOPHILIZATION OF PHARMACEUTICALS; CRYSTALLINE SOLUTES; AMORPHOUS SOLUTES;

D O I：

10.1016/0956-9618(94)80017-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A theory is constructed to describe quantitatively the dynamic behavior of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes. Experimental data for the freeze-drying of cloxacillin monosodium salt and skim milk are obtained using a pilot freeze-dryer The comparison of the theoretical results with the experimental data shows that the agreement between experiment and theory is good.

引用

页码：144 / 155

页数：12

共 32 条

[1]

Mellor, Fundamentals of freeze Drying, (1978)

[2]

Holland, Liapis, Computer methods for solving dynamic separation problems, (1983)

[3]

van, The application of freeze drying in the chemical processing industry, ChemSa, pp. 182-184, (1988)

[4]

Belter, Cussler, Hu, Bioseparations–Downstream Processing for Biotechnology, (1988)

[5]

Liapis, Bruttini, Freeze drying, Handbook of Industrial Drying, (1994)

[6]

Liapis, Litchfield, Optimal control of a freeze dryer: I. Theoretical development and quasisteady-state analysis, Chem. Eng. Sci., 34, pp. 975-981, (1979)

[7]

Litchfield, Liapis, Optimal control of a freeze dryer: II. Dynamic analysis, Chem. Eng. Sci., 37, pp. 45-55, (1982)

[8]

Litchfield, Farhadpour, Liapis, Cyclical pressure freeze drying, Chem. Eng. Sci., 36, pp. 1233-1238, (1981)

[9]

Millman, Liapis, Marchello, An analysis of the lyophilization process using a sorption-sublimation model and various operational policies, AIChE J., 31, pp. 1594-1604, (1985)

[10]

Livesey, Rowe, A discussion of the effect of chamber pressure on heat and mass transfer in freeze-drying, J. Parent. Sci. Technol., 41, pp. 169-171, (1987)

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