A THEORY FOR THE PRIMARY AND SECONDARY DRYING STAGES OF THE FREEZE-DRYING OF PHARMACEUTICAL CRYSTALLINE AND AMORPHOUS SOLUTES - COMPARISON BETWEEN EXPERIMENTAL-DATA AND THEORY

被引：77

作者：

LIAPIS, AI

BRUTTINI, R

机构：

[1] Department of Chemical Engineering, Biochemical Processing Institute, University of Missouri-Rolla, Rolla, MO

来源：

SEPARATIONS TECHNOLOGY | 1994年 / 4卷 / 03期

关键词：

FREEZE-DRYING OF PHARMACEUTICALS; LYOPHILIZATION OF PHARMACEUTICALS; CRYSTALLINE SOLUTES; AMORPHOUS SOLUTES;

D O I：

10.1016/0956-9618(94)80017-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A theory is constructed to describe quantitatively the dynamic behavior of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes. Experimental data for the freeze-drying of cloxacillin monosodium salt and skim milk are obtained using a pilot freeze-dryer The comparison of the theoretical results with the experimental data shows that the agreement between experiment and theory is good.

引用

页码：144 / 155

页数：12