SOMATIC CURRENTS CONTRIBUTE TO FREQUENCY-DEPENDENT SPIKE-BROADENING IN SUPRAOPTIC NEUROENDOCRINE CELLS

被引：16

作者：

OREGAN, MH ^{[1
]}

COBBETT, P ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV, DEPT PHARMACOL & TOXICOL, LIFE SCI BLDG, E LANSING, MI 48824 USA

来源：

NEUROSCIENCE LETTERS | 1993年 / 161卷 / 02期

关键词：

K-CURRENT; CA CURRENT; SUPRAOPTIC NUCLEUS; SPIKE-BROADENING;

D O I：

10.1016/0304-3940(93)90286-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Voltage-gated K and Ca currents were recorded in acutely dissociated neuroendocrine cells of the supraoptic nucleus. The effect of repeated activation of the currents by trains of (10) voltage pulses over a range of pulse-repetition frequencies were examined. There was a significant reduction of K-current amplitude and a significant increase of Ca-current amplitude during trains with high repetition frequencies. Frequency-dependent changes in K and Ca conductances may contribute to frequency-dependent spike-broadening which is exhibited during bursts of action potentials generated by these neurons.

引用

页码：169 / 173

页数：5

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