THE PREPARATION AND CHARACTERIZATION OF POLY(LACTIDE-CO-GLYCOLIDE) MICROPARTICLES .1. OIL-IN-WATER EMULSION SOLVENT EVAPORATION

被引：177

作者：

JEFFERY, H

DAVIS, SS

OHAGAN, DT

机构：

[1] Department of Pharmaceutical Sciences, University of Nottingham, Nottingham

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 77卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

POLY(LACTIDE-CO-GLYCOLIDE); BIODEGRADABLE MICROPARTICLES; SOLVENT EVAPORATION; OIL-IN-WATER EMULSION;

D O I：

10.1016/0378-5173(91)90314-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An oil-in-water emulsion solvent evaporation technique has been used to prepare poly(lactide-co-glycolide) (PLGA) microparticles and the effect of various process parameters on particle size has been investigated. Particles of below 3-mu-m mean particle size were prepared by using a relatively small amount of polymer, a high stirring rate and a low volume of aqueous phase containing a high concentration of surfactant.

引用

页码：169 / 175

页数：7