DIURETIC AND NATRIURETIC EFFECT OF A BRAIN SOLUBLE FRACTION THAT INHIBITS NEURONAL NA plus ,K plus -ATPASE

被引：11

作者：

NOWICKI, S

ENERO, MA

ARNAIZ, GRD

机构：

[1] UNIV BUENOS AIRES, FAC MED,INST BIOL CELULAR, RA-1121 BUENOS AIRES, ARGENTINA

[2] UNIV BUENOS AIRES, FAC FARM & BIOQUIM,CATEDRA FARMACOL, RA-1121 BUENOS AIRES, ARGENTINA

[3] UNIV BUENOS AIRES, FAC FARM & BIOQUIM, ININFA, CONSEJO NACL INVEST CIENT & TECN, RA-1121 BUENOS AIRES, ARGENTINA

来源：

LIFE SCIENCES | 1990年 / 47卷 / 13期

关键词：

D O I：

10.1016/0024-3205(90)90167-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The separation by Sephadex G-50 of two subfractions, peak I and II, from the brain soluble fraction has been previously described. These fractions were able to stimulate and inhibit synaptosomal membrane Na+, K+ -ATPase, respectively (Rodríguez de Lorez Arnaiz and Antonelli de Gómez de Lima, Neurochem. Res. 11, 933-948, 1986). Experimental evidence indicates that the alteration of Na+, K+ -ATPase activity may result in changes of renal and cardiovascular parameters. In the present study, we have analyzed the effect of peak I and II fractions prepared from rat cerebral cortex on water and sodium excretion and on heart rate and arterial pressure in normotensive anesthetized rats. It was observed that water and sodium excretion were not modified by the adminsitration of peak I fraction but that they were increased by peak II fraction. The cardiovascular parameters were not significantly modified by either of the fractions. The results indicate that brain soluble factor (s) which is (are) present in peak II fraction may modify some aspects of renal physiology after systemic administration. © 1990.

引用

页码：1091 / 1098

页数：8