REVERSAL OF AGE-ASSOCIATED DECLINE IN IMMUNE-RESPONSE TO PNU-IMMUNE VACCINE BY SUPPLEMENTATION WITH THE STEROID-HORMONE DEHYDROEPIANDROSTERONE

被引：29

作者：

GARG, M ^{[1
]}

BONDADA, S ^{[1
]}

机构：

[1] UNIV KENTUCKY, DEPT MICROBIOL & IMMUNOL, SANDERS BROWN CTR AGING, LEXINGTON, KY 40536 USA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 05期

关键词：

D O I：

10.1128/IAI.61.5.2238-2241.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, we reported that murine antibody responses to the 23-valent pneumococcal polysaccharide (Pnu-Imune) vaccine declined with age. Here we present data to support the concept that age-associated immune defects are not only due to intrinsic defects in immune cells but are also due to extrinsic factors emanating from the neuroendocrine system. We found that supplementation with dehydroepiandrosterone, a steroid hormone known to be reduced in the aged, corrects the immune deficiency of aged mice and significantly enhanced their splenic immune responses to the Pnu-Imune vaccine.

引用

页码：2238 / 2241

页数：4

共 23 条

[1] DIHYDROTESTOSTERONE EXERTS A DEPRESSIVE INFLUENCE ON THE PRODUCTION OF INTERLEUKIN-4 (IL-4), IL-5, AND GAMMA-INTERFERON, BUT NOT IL-2 BY ACTIVATED MURINE T-CELLS [J].

ARANEO, BA ;

DOWELL, T ;

DIEGEL, M ;

DAYNES, RA .

BLOOD, 1991, 78 (03) :688-699

[2]

DAYNES R A, 1992, Aging Immunology and Infectious Disease, V3, P135

[3] REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .3. THE LYMPHOID-TISSUE MICROENVIRONMENT EXERTS REGULATORY INFLUENCES OVER T-HELPER CELL-FUNCTION [J].

DAYNES, RA ;

ARANEO, BA ;

DOWELL, TA ;

HUANG, K ;

DUDLEY, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :979-996

[4] REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .2. DEHYDROEPIANDROSTERONE IS A NATURAL ENHANCER OF INTERLEUKIN-2 SYNTHESIS BY HELPER T-CELLS [J].

DAYNES, RA ;

DUDLEY, DJ ;

ARANEO, BA .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (04) :793-802

[5] IMMUNE-RESPONSES OF SYSTEMIC AND MUCOSAL LYMPHOID ORGANS TO PNU-IMUNE VACCINE AS A FUNCTION OF AGE AND THE EFFICACY OF MONOPHOSPHORYL LIPID-A AS AN ADJUVANT [J].

GARG, M ;

SUBBARAO, B .

INFECTION AND IMMUNITY, 1992, 60 (06) :2329-2336

[6]

GARG M, UNPUB

[7] IMMUNOLOGICAL STUDIES OF AGING - DECREASED PRODUCTION OF AND RESPONSE TO T-CELL GROWTH-FACTOR BY LYMPHOCYTES FROM AGED HUMANS [J].

GILLIS, S ;

KOZAK, R ;

DURANTE, M ;

WEKSLER, ME .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (04) :937-942

[8] PRIMING OF PERIPHERAL LYMPH-NODE B-CELLS WITH TNP-FICOLL - ROLE OF LYMPHOKINES IN B-CELL DIFFERENTIATION [J].

GOUD, SN ;

KAPLAN, AM ;

SUBBARAO, B .

CELLULAR IMMUNOLOGY, 1992, 144 (02) :407-416

[9]

GOUD SN, 1988, J IMMUNOL, V140, P2925

[10] CLINICAL AND EPIDEMIOLOGIC STUDIES OF PNEUMOCOCCAL INFECTION IN CHILDREN [J].

GRAY, BM ;

DILLON, HC .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1986, 5 (02) :201-207

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