REVERSAL OF AGE-ASSOCIATED DECLINE IN IMMUNE-RESPONSE TO PNU-IMMUNE VACCINE BY SUPPLEMENTATION WITH THE STEROID-HORMONE DEHYDROEPIANDROSTERONE

被引：29

作者：

GARG, M ^{[1
]}

BONDADA, S ^{[1
]}

机构：

[1] UNIV KENTUCKY, DEPT MICROBIOL & IMMUNOL, SANDERS BROWN CTR AGING, LEXINGTON, KY 40536 USA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 05期

关键词：

D O I：

10.1128/IAI.61.5.2238-2241.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, we reported that murine antibody responses to the 23-valent pneumococcal polysaccharide (Pnu-Imune) vaccine declined with age. Here we present data to support the concept that age-associated immune defects are not only due to intrinsic defects in immune cells but are also due to extrinsic factors emanating from the neuroendocrine system. We found that supplementation with dehydroepiandrosterone, a steroid hormone known to be reduced in the aged, corrects the immune deficiency of aged mice and significantly enhanced their splenic immune responses to the Pnu-Imune vaccine.

引用

页码：2238 / 2241

页数：4

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