MUTAGENICITY AND GENOTOXICITY OF ETHYLVINYL KETONE IN BACTERIAL TESTS

被引：18

作者：

DEININGER, C

EDER, E

NEUDECKER, T

HOFFMAN, C

机构：

[1] Institute of Toxicology, University of Würzburg, Würzburg, D-8700

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1990年 / 10卷 / 03期

关键词：

ethylvinyl ketone; Salmonella mutagenicity; SOS Chromotest;

D O I：

10.1002/jat.2550100305

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The mutagenic and genotoxic effects of ethylvinyl ketone were investigated. This α, β‐unsaturated carbonyl compound is widely distributed in the environment, in particular in food. Whereas ethylvinyl ketone shows only weak genotoxicity in the SOS Chromotest with Escherichia coli PQ37, it was distinctly mutagenic per se in the Salmonella preincubation assay with TA100. Using SKF 525 (an inhibitor of microsomal monooxygenase) and trichloropropene oxide (an inhibitor of epoxide hydrolase) we found indication for additional activation via epoxidation by S9 mix. The need for further investigation of the genotoxic, mutagenic and carcinogenic effects of this compound is strongly indicated. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：167 / 171

页数：5

共 31 条

[1]

BAKER RR, 1984, ANAL P LONDON, V21, P135

[2] IDENTIFICATION OF ADDUCTS FORMED BY REACTION OF GUANINE NUCLEOSIDES WITH MALONDIALDEHYDE AND STRUCTURALLY RELATED ALDEHYDES [J].