A NEW SYNTHETIC APPROACH TO 5-DEAZAFLAVIN AND 5-DEAZA-10-THIAFLAVIN

被引：7

作者：

CHEN, X ^{[1
]}

TANAKA, K ^{[1
]}

YONEDA, F ^{[1
]}

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, SAKYO KU, KYOTO 606, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 03期

关键词：

5-deaza-10-thiaflavin; 5-deazaflavin; coenzyme model; hetero Diels-Alder; one-step synthesis; reaction; redox potential;

D O I：

10.1248/cpb.38.612

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel, one-step synthesis of 5-deazaflavin was developed, in which a [4 + 2\cycloaddition is presumably involved, to give the 5-deazaflavin derivative in moderate yield. This methodology was successfully applied to the stepwise preparation of its thio analogue, 5-deaza-10-thiaflavin, whose 1,5-dihydro derivative was transformed into the corresponding sulfone in good yield. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：612 / 615

页数：4

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