CAENORHABDITIS-ELEGANS EXPRESSED SEQUENCE TAGS IDENTIFY GENE FAMILIES AND POTENTIAL DISEASE GENE HOMOLOGS

被引：164

作者：

MCCOMBIE, WR ^{[1
]}

ADAMS, MD ^{[1
]}

KELLEY, JM ^{[1
]}

FITZGERALD, MG ^{[1
]}

UTTERBACK, TR ^{[1
]}

KHAN, M ^{[1
]}

DUBNICK, M ^{[1
]}

KERLAVAGE, AR ^{[1
]}

VENTER, JC ^{[1
]}

FIELDS, C ^{[1
]}

机构：

[1] NINCDS, RECEPTOR BIOCHEM & MOLEC BIOL SECT, PK BLDG, ROOM 405, BETHESDA, MD 20892 USA

来源：

NATURE GENETICS | 1992年 / 1卷 / 02期

关键词：

D O I：

10.1038/ng0592-124

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A database containing mapped partial cDNA sequences from Caenorhabdhitis elegans will provide a ready starting point for identifying nematode homologues of important human genes and determining their functions in C. elegans. A total of 720 expressed sequence tags (ESTs) have been generated from 585 clones randomly selected from a mixed-stage C. elegans cDNA library. Comparison of these ESTs with sequence databases identified 422 new C. elegans genes, of which 317 are not similar to any sequences in the database. Twenty-six new genes have been mapped by YAC clone hybridization. Members of several gene families, including cuticle collagens, GTP-binding proteins, and RNA helicases were discovered. Many of the new genes are similar to known or potential human disease genes, including CFTR and the LDL receptor.

引用

页码：124 / 131

页数：8

共 48 条

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