SELECTIVE LOCALIZATION OF STRIATAL D1 RECEPTORS TO STRIATONIGRAL NEURONS

被引：149

作者：

HARRISON, MB

WILEY, RG

WOOTEN, GF

机构：

[1] VANDERBILT UNIV,DEPT NEUROL,NASHVILLE,TN 37212

[2] VANDERBILT UNIV,DEPT PHARMACOL,NASHVILLE,TN 37212

来源：

BRAIN RESEARCH | 1990年 / 528卷 / 02期

关键词：

D[!sub]1[!/sub] receptor; Quantitative autoradiography; Striatonigral projection; Suicide transport; Volkensin;

D O I：

10.1016/0006-8993(90)91674-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A new technique for producing anatomically selective lesions within the brain was used to investigate the cellular localization of the D1 and D2 receptor. The cytotoxic lectin, volkensin, is taken up by nerve terminals and retrogradely transported, killing those neurons projecting to the site of injection. Comparison of D1 and D2 binding following a unilateral volkensin injection into the substantia nigra has demonstrated that striatal D1 binding sites are selectively localized to striatonigral projection neurons. © 1990.

引用

页码：317 / 322

页数：6

共 30 条

[21] 6-HYDROXYDOPAMINE-INDUCED DEGENERATION OF NIGRAL DOPAMINE NEURONS - DIFFERENTIAL EFFECT ON NIGRAL AND STRIATAL D-1 DOPAMINE-RECEPTORS [J].