INTRAPERITONEAL ADMINISTRATION OF RECOMBINANT HUMAN INTERLEUKIN-1-BETA INHIBITS OSMOTIC THIRST IN THE RAT

被引：27

作者：

OSAKA, T ^{[1
]}

KANNAN, H ^{[1
]}

KAWANO, S ^{[1
]}

UETA, Y ^{[1
]}

YAMASHITA, H ^{[1
]}

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT PHYSIOL,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 06期

关键词：

DRINKING BEHAVIOR; INTERLEUKIN-1-BETA; HYPERTONIC SALINE; INDOMETHACIN;

D O I：

10.1016/0031-9384(92)90319-W

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Decrease in water intake after intraperitoneal injection of interleukin-1-beta (IL-1-beta) was studied in the rat. Administration of IL-1-beta at a dose of 20-mu-g/kg attenuated osmotic thirst induced by intraperitoneal injection of hypertonic saline, but did not affect hypovolemic thirst induced by subcutaneous injection of either polyethylene glycol or angiotensin II. Interleukin-1-beta also decreased spontaneous intake of water but not that of 1.8% saline. The results suggest that the decrease in water intake by IL-1-beta is caused, at least in part, by suppression of osmotic thirst but not by general suppression of behavior. The effects of IL-1-beta were not secondary responses accompanied by feeding behavior, since food supply was removed during the experiments. Pretreatment with indomethacin blocked the decrease in water intake by IL-1-beta, suggesting the involvement of production of prostaglandins.

引用

页码：1267 / 1270

页数：4

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