INTRAPERITONEAL ADMINISTRATION OF RECOMBINANT HUMAN INTERLEUKIN-1-BETA INHIBITS OSMOTIC THIRST IN THE RAT

被引：27

作者：

OSAKA, T ^{[1
]}

KANNAN, H ^{[1
]}

KAWANO, S ^{[1
]}

UETA, Y ^{[1
]}

YAMASHITA, H ^{[1
]}

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT PHYSIOL,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 06期

关键词：

DRINKING BEHAVIOR; INTERLEUKIN-1-BETA; HYPERTONIC SALINE; INDOMETHACIN;

D O I：

10.1016/0031-9384(92)90319-W

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Decrease in water intake after intraperitoneal injection of interleukin-1-beta (IL-1-beta) was studied in the rat. Administration of IL-1-beta at a dose of 20-mu-g/kg attenuated osmotic thirst induced by intraperitoneal injection of hypertonic saline, but did not affect hypovolemic thirst induced by subcutaneous injection of either polyethylene glycol or angiotensin II. Interleukin-1-beta also decreased spontaneous intake of water but not that of 1.8% saline. The results suggest that the decrease in water intake by IL-1-beta is caused, at least in part, by suppression of osmotic thirst but not by general suppression of behavior. The effects of IL-1-beta were not secondary responses accompanied by feeding behavior, since food supply was removed during the experiments. Pretreatment with indomethacin blocked the decrease in water intake by IL-1-beta, suggesting the involvement of production of prostaglandins.

引用

页码：1267 / 1270

页数：4

共 26 条

[21] THIRST AND RENAL EXCRETION OF WATER AND ELECTROLYTES DURING PYROGEN FEVER IN DOGS [J].

SZCZEPANSKASADOWSKA, E ;

SOBOCINSKA, J ;

KOZLOWSKI, S .

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1979, 87 (04) :673-686

[22] CENTRAL DIPSOGENIC EFFECT OF VASOPRESSIN [J].

SZCZEPANSKASADOWSKA, E ;

SOBOCINSKA, J ;

SADOWSKI, B .

AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 242 (03) :R372-R379

[23] INTERLEUKIN-1 INDUCES CONDITIONED TASTE-AVERSION IN RATS - A POSSIBLE EXPLANATION FOR ITS PITUITARY-ADRENAL STIMULATING ACTIVITY [J].

TAZI, A ;

DANTZER, R ;

CRESTANI, F ;

LEMOAL, M .

BRAIN RESEARCH, 1988, 473 (02) :369-371

[24] INDOMETHACIN BLOCKS THE ANOREXIC ACTION OF INTERLEUKIN-1 [J].

UEHARA, A ;

ISHIKAWA, Y ;

OKUMURA, T ;

OKAMURA, K ;

SEKIYA, C ;

TAKASUGI, Y ;

NAMIKI, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 170 (03) :257-260

[25] STIMULATION OF ACTH RELEASE BY HUMAN INTERLEUKIN-1-BETA, BUT NOT BY INTERLEUKIN-1-ALPHA, IN CONSCIOUS, FREELY-MOVING RATS [J].

UEHARA, A ;

GOTTSCHALL, PE ;

DAHL, RR ;

ARIMURA, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (03) :1286-1290

[26] REDUCTION OF THE SEVERITY OF EXPERIMENTAL GASTRIC AND DUODENAL ULCERATION BY INTERLEUKIN-1-BETA [J].

WALLACE, JL ;

KEENAN, CM ;

MUGRIDGE, KG ;

PARENTE, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 186 (2-3) :279-284

← 1 2 3 →