DETERMINATION OF DOPAMINE AND ITS METABOLITES IN MICRODIALYSATES BY CAPILLARY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引:8
作者
RUBAN, VF
机构
[1] Institute of Macromolecular Compounds, Russian Academy of Science
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 619卷 / 01期
关键词
D O I
10.1016/0378-4347(93)80452-A
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A liquid chromatographic method with packed fused-silica capillary columns and amperometric detection for the determination of trace amounts of catecholamines in microdialysis samples has been developed. The analysis time for dopamine and the products of its metabolism does not exceed 10 min. The minimum detectable dopamine concentration in a 2-mul sample is 0.05 mug/l. The relative standard deviation in concentration determinations is +/-0.03 (n = 10). The small sample volume required and the speed of analysis make it possible to analyse biologically important compounds with a rapidly changing concentration.
引用
收藏
页码:111 / 115
页数:5
相关论文
共 11 条
  • [1] CHURCH WH, 1989, ADV CHROAMTOGRAPHY
  • [2] HUANG T, 1990, CURRENT SEP, V9, P139
  • [3] SAMPLING AND EXTRA-COLUMN EFFECTS IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - INFLUENCE OF PEAK SKEW ON PLATE COUNT CALCULATIONS
    KIRKLAND, JJ
    YAU, WW
    STOKLOSA, HJ
    DILKS, CH
    [J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1977, 15 (08) : 303 - 316
  • [4] KISSINGER CB, 1990, AM LAB, V22, P94
  • [5] RECENT ADVANCES IN MICROCOLUMN LIQUID-CHROMATOGRAPHY
    NOVOTNY, M
    [J]. ANALYTICAL CHEMISTRY, 1988, 60 (08) : A500 - &
  • [6] STUDY OF THE CHARACTERISTICS AND ANALYTICAL APPLICATION OF A CAPILLARY CHROMATOGRAPH WITH AN ELECTROCHEMICAL DETECTOR
    RUBAN, VF
    ANISIMOVA, IA
    BELENKII, BG
    [J]. JOURNAL OF CHROMATOGRAPHY, 1990, 520 : 307 - 313
  • [7] LIQUID-CHROMATOGRAPHY ON PACKED FUSED-SILICA CAPILLARY COLUMNS WITH ELECTROCHEMICAL DETECTION
    RUBAN, VF
    BELENKII, AB
    GUREVICH, AY
    BELENKII, BG
    [J]. JOURNAL OF CHROMATOGRAPHY, 1989, 467 (01): : 41 - 47
  • [8] RUBAN VF, 1990, J HIGH RES CHROMATOG, V13, P12
  • [9] RUBAN VF, 1991, ZH ANAL KHIM, V46, P891
  • [10] RAPID MEASUREMENT OF DOPAMINE RELEASE USING BRAIN DIALYSIS COMBINED WITH MICROBORE HPLC
    SHARP, T
    CARLSSON, A
    ZETTERSTROM, T
    LUNDSTROM, K
    UNGERSTEDT, U
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 473 : 512 - 515