学术探索
学术期刊
新闻热点
数据分析
智能评审
立即登录
TERATOGENIC EFFECTS OF NEONATAL ARENAVIRUS INFECTION ON THE DEVELOPING RAT CEREBELLUM ARE ABROGATED BY PASSIVE IMMUNOTHERAPY
被引:22
作者
:
BALDRIDGE, JR
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
BALDRIDGE, JR
[
1
]
PEARCE, BD
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
PEARCE, BD
[
1
]
PAREKH, BS
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
PAREKH, BS
[
1
]
BUCHMEIER, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
BUCHMEIER, MJ
[
1
]
机构
:
[1]
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
来源
:
VIROLOGY
|
1993年
/ 197卷
/ 02期
关键词
:
D O I
:
10.1006/viro.1993.1642
中图分类号
:
Q93 [微生物学];
学科分类号
:
071005 ;
100705 ;
摘要
:
The effects of viral infection on the developing nervous system and the potential of passive immunotherapy to protect against infection were examined. When 4-day-old Lewis rats were injected intracerebrally with lymphocytic choriomeningitis virus (LCMV) the majority of stem cells within the external granular layer of the developing cerebellum became infected. The infection progressed to the molecular layer, internal granular layer, and the Purkinje cells. By 15 days postinfection the molecular and internal granular layers of LCMV-infected cerebella were noticeably thinner than those in the controls and the individual folia were smaller. Neurons remained infected for up to 40 days as determined by immunohistochemistry. However, in rats treated with rat monoclonal anti-LCMV antibodies the staining was limited to the cells of and choroid plexus and was not detectable by 15 days postinfection. Macroscopically the infection resulted in pronounced hypoplasia, with the cerebella of 21-day-old LCMV-infected rats weighing 52 ± 10 mg compared with 159 ± 30 mg for control rats. Antibody-treated rats exhibited normal cerebellar size and development. Neutralizing antibodies specific for the viral GP-1 glycoprotein were protective but nucleoprotein-specific antibodies were not. Furthermore, suckling rat pups born of and nursed by LCMV-immune mothers were spared from cerebellar disease following neonatal infection. These results suggest that passive immunotherapy of neonates can provide effective protection against teratogenic effects of neonatal viral infection on the developing CNS. © 1993 Academic Press, Inc.
引用
收藏
页码:669 / 677
页数:9
相关论文
共 33 条
[31]
ANTIVIRAL ANTIBODIES ATTENUATE T-CELL-MEDIATED IMMUNOPATHOLOGY FOLLOWING ACUTE LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION
WRIGHT, KE
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
WRIGHT, KE
BUCHMEIER, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
BUCHMEIER, MJ
[J].
JOURNAL OF VIROLOGY,
1991,
65
(06)
: 3001
-
3006
[32]
NEUTRALIZING EPITOPES OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS ARE CONFORMATIONAL AND REQUIRE BOTH GLYCOSYLATION AND DISULFIDE BONDS FOR EXPRESSION
WRIGHT, KE
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
WRIGHT, KE
SALVATO, MS
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SALVATO, MS
BUCHMEIER, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
BUCHMEIER, MJ
[J].
VIROLOGY,
1989,
171
(02)
: 417
-
426
[33]
MECHANISMS AND PATHWAYS OF CONGENITAL INFECTIONS
ZEICHNER, SL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN,SCH MED,PHILADELPHIA,PA 19104
ZEICHNER, SL
PLOTKIN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN,SCH MED,PHILADELPHIA,PA 19104
PLOTKIN, SA
[J].
CLINICS IN PERINATOLOGY,
1988,
15
(02)
: 163
-
188
←
1
2
3
4
→
共 33 条
[31]
ANTIVIRAL ANTIBODIES ATTENUATE T-CELL-MEDIATED IMMUNOPATHOLOGY FOLLOWING ACUTE LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION
WRIGHT, KE
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
WRIGHT, KE
BUCHMEIER, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
BUCHMEIER, MJ
[J].
JOURNAL OF VIROLOGY,
1991,
65
(06)
: 3001
-
3006
[32]
NEUTRALIZING EPITOPES OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS ARE CONFORMATIONAL AND REQUIRE BOTH GLYCOSYLATION AND DISULFIDE BONDS FOR EXPRESSION
WRIGHT, KE
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
WRIGHT, KE
SALVATO, MS
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SALVATO, MS
BUCHMEIER, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
SCRIPPS CLIN & RES FDN, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
BUCHMEIER, MJ
[J].
VIROLOGY,
1989,
171
(02)
: 417
-
426
[33]
MECHANISMS AND PATHWAYS OF CONGENITAL INFECTIONS
ZEICHNER, SL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN,SCH MED,PHILADELPHIA,PA 19104
ZEICHNER, SL
PLOTKIN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN,SCH MED,PHILADELPHIA,PA 19104
PLOTKIN, SA
[J].
CLINICS IN PERINATOLOGY,
1988,
15
(02)
: 163
-
188
←
1
2
3
4
→