RECEPTOR-BASED DESIGN OF DIHYDROFOLATE-REDUCTASE INHIBITORS - COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY-SUBSTITUTED TRIMETHOPRIM ANALOGS

被引：72

作者：

KUYPER, LF ^{[1
]}

ROTH, B ^{[1
]}

BACCANARI, DP ^{[1
]}

FERONE, R ^{[1
]}

BEDDELL, CR ^{[1
]}

CHAMPNESS, JN ^{[1
]}

STAMMERS, DK ^{[1
]}

DANN, JG ^{[1
]}

NORRINGTON, FEA ^{[1
]}

BAKER, DJ ^{[1
]}

GOODFORD, PJ ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1982年 / 25卷 / 10期

关键词：

D O I：

10.1021/jm00352a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1120 / 1122

页数：3

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