PLASTIC MEMBRANE-ELECTRODE FOR SELECTIVE DETERMINATION OF DICLOFENAC (VOLTAREN) IN PHARMACEUTICAL PREPARATIONS

被引：37

作者：

HASSAN, SSM ^{[1
]}

ABDELAZIZ, RM ^{[1
]}

ABDELSAMAD, MS ^{[1
]}

机构：

[1] EL NASR PHARMACEUT CHEM CO,CAIRO,EGYPT

来源：

ANALYST | 1994年 / 119卷 / 09期

关键词：

ION-SELECTIVE ELECTRODE; DICLOFENAC-NICKEL(II); BATHOPHENANTHROLINE; POLY(VINYL CHLORIDE) MATRIX MEMBRANE; PHARMACEUTICAL ANALYSIS;

D O I：

10.1039/an9941901993

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel plastic membrane ion-selective electrode for determining the diclofenac anion is described. The sensing membrane of the electrode consists of diclofenac-nickel(II) bathophenanthroline as an ion-exchanger site in a poly(vinyl chloride) matrix plasticized with o-nitrophenyl phenyl ether. In berate buffer solutions of pH 8-12, the electrode exhibits a fast, stable and linear response for 1 X 10(-2)-5 x 10(-5) mol dm(-3) diclofenac with an anionic slope of 55.1 +/- 0.2 mV decade(-1) at 25 degrees C. Potentiometric selectivity measurements revealed negligible interferences from 14 different anions including aromatic and aliphatic carboxylic acid salts. The electrode displays useful analytical characteristics for the direct determination of diclofenac in various pharmaceutical preparations. Results with an average recovery of 98 +/- 0.6% of the nominal value were obtained.

引用

页码：1993 / 1996

页数：4

共 25 条

[1] COLORIMETRIC DETERMINATION OF 7 NONSTEROIDAL ANTIINFLAMMATORY DRUGS USING 2-NITROPHENYLHYDRAZINE HYDROCHLORIDE [J].