THE CELL-CYCLE, SIGNAL-TRANSDUCTION, AND IMMUNOPHILIN LIGAND COMPLEXES

被引：83

作者：

SCHREIBER, SL

ALBERS, MW

BROWN, EJ

机构：

[1] HARVARD UNIV,GRAD PROGRAM BIOPHYS,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,SCH MED,GRAD PROGRAM IMMUNOL,BOSTON,MA 02115

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 1993年 / 26卷 / 08期

关键词：

D O I：

10.1021/ar00032a004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we have illustrated the use of two natural products to explore the signaling processes involved in G0 to G1 and G1 to S phase transitions. Through their ability to specifically inhibit cellular processes, natural products serve as molecular probes to define critical components of complicated biochemical events. Thus, natural products chemistry in alliance with tools such as flow cytometry provide an excellent opportunity for chemists to meet the challenge of deciphering biological processes at a molecular level. © 1993, American Chemical Society. All rights reserved.

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页码：412 / 420

页数：9

相关论文

共 40 条

[11] NUCLEAR-ASSOCIATION OF A T-CELL TRANSCRIPTION FACTOR BLOCKED BY FK-506 AND CYCLOSPORINE-A [J].

FLANAGAN, WM ;

CORTHESY, B ;

BRAM, RJ ;

CRABTREE, GR .

NATURE, 1991, 352 (6338) :803-807

[12] REGULATION OF INTERLEUKIN-2 GENE ENHANCER ACTIVITY BY THE T-CELL ACCESSORY MOLECULE CD28 [J].

FRASER, JD ;

IRVING, BA ;

CRABTREE, GR ;

WEISS, A .

SCIENCE, 1991, 251 (4991) :313-316

[13]

GIVAN AL, 1992, FLOW CYTOMETRY 1ST P, P202

[14] IDENTIFICATION AND CHARACTERIZATION OF A MITOGEN-ACTIVATED S6 KINASE [J].

JENO, P ;

BALLOU, LM ;

NOVAKHOFER, I ;

THOMAS, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (02) :406-410

[15] RAPAMYCIN SELECTIVELY INHIBITS INTERLEUKIN-2 ACTIVATION OF P70 S6 KINASE [J].

KUO, CJ ;

CHUNG, JK ;

FIORENTINO, DF ;

FLANAGAN, WM ;

BLENIS, J ;

CRABTREE, GR .

NATURE, 1992, 358 (6381) :70-73

[16] CALCINEURIN IS A COMMON TARGET OF CYCLOPHILIN-CYCLOSPORINE-A AND FKBP-FK506 COMPLEXES [J].

LIU, J ;

FARMER, JD ;

LANE, WS ;

FRIEDMAN, J ;

WEISSMAN, I ;

SCHREIBER, SL .

CELL, 1991, 66 (04) :807-815

[17] INHIBITION OF T-CELL SIGNALING BY IMMUNOPHILIN LIGAND COMPLEXES CORRELATES WITH LOSS OF CALCINEURIN PHOSPHATASE-ACTIVITY [J].

LIU, J ;

ALBERS, MW ;

WANDLESS, TJ ;

LUAN, S ;

ALBERG, DG ;

BELSHAW, PJ ;

COHEN, P ;

MACKINTOSH, C ;

KLEE, CB ;

SCHREIBER, SL .

BIOCHEMISTRY, 1992, 31 (16) :3896-3901

[18]

MCCAFFREY PG, 1993, J BIOL CHEM, V268, P3747

[19] A FAMILY OF HUMAN CDC2-RELATED PROTEIN-KINASES [J].

MEYERSON, M ;

ENDERS, GH ;

WU, CL ;

SU, LK ;

GORKA, C ;

NELSON, C ;

HARLOW, E ;

TSAI, LH .

EMBO JOURNAL, 1992, 11 (08) :2909-2917

[20] ANIMAL-CELL CYCLES AND THEIR CONTROL [J].

NORBURY, C ;

NURSE, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 :441-470

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