ENZYMATIC REGIOSELECTIVE AND DIASTEREOSELECTIVE HYDROLYSIS OF PERACETYLATED GLYCEROL-BETA-GLUCOSIDES AND ERYTHRITOL-BETA-GLUCOSIDES

被引：6

作者：

SORIENTE, A

DEROSA, M

TRINCONE, A

SODANO, G

机构：

[1] UNIV SALERNO, DIPARTIMENTO CHIM, I-84081 BARONISSI, ITALY

[2] CNR, IST CHIM MOLEC INTERESSE BIOL, I-80072 Arco Felice Napoli, ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 20期

关键词：

D O I：

10.1016/0960-894X(95)00402-F

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diastereomeric O-beta-glucosides at the primary carbons of glycerol and erythritol have been subjected as their peracetates to enzymatic hydrolysis by PFL. Only acetyl groups of the aglycones are hydrolyzed, the diastereoselectivity being very high on the erythritol derivatives and fair on the glycerol derivatives. The chemical synthesis of (2S,3R)-1-(O-beta-D-glucopyranosyl)-butane-2,3,4-triol heptaacetate is also reported.

引用

页码：2321 / 2324

页数：4

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