CORRELATION BETWEEN NITRIC-OXIDE SYNTHESIS AND HISTAMINE-RELEASE IN MAST-CELLS FROM SPONTANEOUSLY HYPERTENSIVE RATS - INFLUENCE OF AGING

被引：3

作者：

MASINI, E

GAMBASSI, F

LUPINI, M

PISTELLI, A

MANNAIONI, PF

机构：

[1] Department of Preclinical and Clinical Pharmacology, University of Florence

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1992年 / 99卷 / 2-4期

关键词：

NITRIC OXIDE; HISTAMINE; AGING; RAT MAST CELLS; HEART;

D O I：

10.1159/000236297

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Isolated perfused hearts and serosal mast cells (MC) of 2-, 6- and 18-month-old spontaneously hypertensive rats (SH) were compared to hearts and MC from Wistar-Kyoto (WKY) rats of the same age for their ability to release nitric oxide (NO). The relationship between histamine release and NO production was also investigated. In hearts and MC of 2-, 6- and 18-month-old SH rats, the production of NO is significantly lower than in hearts or MC of WKY rats of the same age. Concomitantly, the spontaneous release of histamine in cardiac perfusates and MC reactivity to various exocytotic stimuli (compound 48/80, calcium ionophore A 23187) is modified by aging and hypertension.

引用

页码：404 / 407

页数：4

共 16 条

[1]

Bergmeyer HU, 1974, METHOD ENZYMAT AN, P574

[2]

BORN GVR, 1963, J PHYSIOL-LONDON, V168, P178, DOI 10.1113/jphysiol.1963.sp007185

[3] ENDOTHELIUM-DERIVED RELAXING FACTOR PRODUCED AND RELEASED FROM ARTERY AND VEIN IS NITRIC-OXIDE [J].